Publications 2020-2025

1. Liao H, Ahmed M, MD, Markezana A, Zeng G, Stechele M, Galun E, Goldberg, NS. (2020). Thermal ablation induces time-dependent transitory intrahepatic metastatic growth via the STAT3/c-Met molecular pathway.

Radiology 294:464-472.

2. Guedj A, Volman Y, Geiger-Maor A, Bolik J, Schumacher N, Künzel S, Baines JF, Nevo Y, Elgavish S, Galun E, Amsalem H, Schmidt-Arras D, Rachmilewitz J. (2020). Gut microbiota shape “inflamm-aging” cytokines and account for age-dependent decline in DNA damage repair. Gut 69:1064-1075.

3. Markezana A, Ahmed M, Kumar G, Zorde-Khvalevsky E, Rozenblum N, Galun E, Goldberg SN. (2021) Moderate hyperthermic heating encountered during thermal ablation increases tumor cell activity. Int J Hyperthermia. 37:119-129.

4. Levite M, Zelig D, Friedman A, Ilouz N, Eilam R, Bromberg Z, Ramadhan Lasu AA, Arbel-Alon S, Edvardson S, Tarshish M, Riek LP, Lako RL, Reubinoff B, Lebendiker M, Yaish D, Stavsky A, Galun E. (2020). Dual-targeted Autoimmune Sword in Fatal Epilepsy: Patient’s glutamate receptor AMPA GluR3 autoimmune antibodies bind, induce ROS, and kill both human neural cells and T cells. J of Autoimmunity (in press).

5. Chai C, Cox B, Yaish D, Gross D, Rosenberg N, Amblard F, Shemuelian Z, Gefen M, Korach A, Tirosh O, Lanton T, Link H, Tam J, Permikov A, Ozhan G, Citrin J, Liao H, Tannous M, Hahn M, Axelrod J, Arretxe E, Alonso E, Martinez- Arranz I, Ortiz Betés P, Safadi R, Salhab A, Amer J, Tber Z, Mengshetti S, Giladi H, Schinazi RF, Galun E. (2020). Agonist of RORA Reduces Progression of Fatty Liver in Mice via Upregulation of microRNA 122.

Gastroenterology 159:999-1014. Response letter to the editor: Chai C, Giladi H, Galun E. (2021).

Gastroenterology 160:1882-1883.

6. Benedek G, El Latif MA, Miller K, Rivkin M, Lasu AAR, Riek LP , Lako R, Edvardson S, Arbel-Alon S, Galun E,

Levite M. (2020). Protection or susceptibility to devastating childhood epilepsy: Nodding Syndrome associates with immunogenetic fingerprints in the HLA binding groove. PLOS Neglected Tropical Diseases 14:e0008436.

7. Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, Zeira E, Halpern KB, Caruso S, Zucman-Rossi J, Axelrod JH, Galun E, Goldenberg DS. 2021. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. Oncogene 40:127-139.

8. Sadeh R , Sharkia I , Fialkoff G , Rahat A , Gutin J, Chappelboim A, Nitzan M , Ilana Fox-Fisher I , Neiman D, Meler G, Kamari Z , Yaish D , Peretz T , Hubert A, Cohen JE , Azzam S, Mark Temper M, Grinshpun A , Maoz M , Abu-Gazala S, Ben Yaacov A , Shteyer E, Safadi R, Kaplan T , Shemer R, Planer D , Galun E , Glaser B, Zick A, Dor Y , Friedman N. 2021. ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programs. Nature Biotechnology 39:586-598.

9. Harari-Steinfeld R, Gefen M, Simerzin A, Zorde-Khvalevski E, Rivkin M, Ella E, Friehmann T, Gerlic M,
Zucman Rossi J, Caruso S, Leveille M, Estall J, Goldenberg DS, Giladi H, Galun E*, Bromberg Z. 2021. The lncRNA H19-derived microRNA-675 Promotes Liver Necroptosis by Targeting FADD. Cancers (in press).

10. Schmidt-Arras D, Galun E, Rose-John S. (2021). The two facets of gp130 signalling in liver tumorigenesis. Seminars in Immunopathology (in press).

11. Levite M, Safadi R, Milgrom Y, Massarwa M, Galun E. (2021). Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells. Neuropeptides (in press).

12. Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, Rosenberg N, Pappo O, Elgavish S, Nevo Y, Safadi R, Peled A, Rose-John S, Galun E*, Axelrod JH. (2021). Decisive Roles of IL-6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis. Cancer Res (in press).

13. Benedek G, El Latif MA, Miller K, Rivkin M, Ramadhan AAL, Riek LP, Lako R, Edvardson S, Arbel Alon S, Galun E, Levite M. (2021). Macrophage migration inhibitory factor in Nodding Syndrome. PLoS Neglected Tropical Diseases (in press).

14. Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, Giladi H, Peled A, Goldenberg DS, Axelrod JH, Simerzin A, Chai C, Paldor M, Markezana A, Yaish D, Shemulian Z, Gross D, Barnoy S, Gefen M, Amran O, Claerhout S, Fernández-Vaquero M, García-Beccaria M, Heide D, Shoshkes-Carmel M, Schmidt Arras D, Elgavish S, Nevo Y, Benyamini H, Tirnitz-Parker JEE, Sanchez A, Herrera B, Safadi R, Kaestner KH, Rose-John S, Roskams T, Heikenwalder M, Galun E.(2022) Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. J Hepatol.77(6):1631-1641. doi: 10.1016/j.jhep.2022.07.029.

15. Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. (2022). Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. J Exp Med.;219(1):e20201039. doi: 10.1084/jem.20201039.

16. Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, Elgavish S, Nevo Y, Benyamini H, Plaschkes I, Klein S, Mali A, Rose-John S, Peled A, Galun E, Axelrod JH. (2022). Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Mol Med.8;14(8):e15653. doi: 10.15252/emmm.202115653.

17. Moussa M, Mwin D, Liao H, Atac MF, Markezana A, Galun E, Goldberg SN, Ahmed M. (2022). Myofibroblasts: A key promoter of tumorigenesis following radiofrequency tumor ablation. PLoS One;17(7):e0266522.

18. Volman Y, Hefetz R, Galun E, Rachmilewitz J.(2022). DNA damage alters EGFR signaling and reprograms cellular response via Mre-11.Sci Rep.;12(1):5760. doi: 10.1038/s41598-022-09779-5.

19. Stechele M, Wildgruber M, Markezana A, Kästle S, Öcal E, Kimm MA, Alunni-Fabbroni M, Paldor M, Haixing L, Salvermoser L, Pech M, Powerski M, Galun E, Ricke J, Goldberg SN. (2023). Prediction of Protumorigenic Effects after Image-Guided Radiofrequency Ablation of Hepatocellular Carcinoma Using Biomarkers. J Vasc Interv Radiol.34(9):1528-1537.e1. doi: 10.1016/j.jvir.2022.11.024.

20. Shmuelian Z, Warszawer Y, Or O, Arbel-Alon S, Giladi H, Avgil Tsadok M, Cohen R, Shefer G, Shlomi D, Hoshen M, Maruotti A, Jona-Lasinio G, Galun E.(2023). Postexposure-vaccine-prophylaxis against COVID-19.JMed Virol.95(1):e28274. doi: 10.1002/jmv.28274.

21. Markezana A, Paldor M, Liao H, Ahmed M, Zorde-Khvalevsky E, Rozenblum N, Stechele M, Salvermoser L, Laville F, Goldmann S, Rosenberg N, Andrasina T, Ricke J, Galun E, Goldberg SN.(2023). Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation. Sci Rep. 2023 Sep 28;13(1):16341. doi: 10.1038/s41598-023-42819-2.

22. Salvermoser L, Goldberg SN, Laville F, Markezana A, Stechele M, Ahmed M, Wildgruber M, Kazmierczak PM, Alunni-Fabbroni M, Galun E, Ricke J, Paldor M.(2023). Radiofrequency Ablation-Induced Tumor Growth Is Suppressed by MicroRNA-21 Inhibition in Murine Models of Intrahepatic Colorectal Carcinoma. J Vasc Interv Radiol.;34(10):1785-1793.e2. doi: 10.1016/j.jvir.2023.06.019.

23. Stechele M, Wildgruber M, Markezana A, Kästle S, Öcal E, Kimm MA, Alunni-Fabbroni M, Paldor M, Haixing L, Salvermoser L, Pech M, Powerski M, Galun E, Ricke J, Goldberg SN. (2023). Prediction of Protumorigenic Effects after Image-Guided Radiofrequency Ablation of Hepatocellular Carcinoma Using Biomarkers. J Vasc Interv Radiol.;34(9):1528-1537.e1. doi: 10.1016/j.jvir.2022.11.024.

24. Stechele M, Link H, Hirner-Eppeneder H, Alunni-Fabbroni M, Wildgruber M, Salvermoser L, Corradini S, Schinner R, Ben Khaled N, Rössler D, Galun E, Goldberg SN, Ricke J, Kazmierczak PM. (2023). Circulating miR-21 as a prognostic biomarker in HCC treated by CT-guided high-dose rate brachytherapy. Radiat Oncol. ;18(1):125. doi: 10.1186/s13014-023-02316-2.

25. Gunes A, Schmitt C, Bilodeau L, Huet C, Belblidia A, Baldwin C, Giard JM, Biertho L, Lafortune A, Couture CY, Cheung A, Nguyen BN, Galun E, Bémeur C, Bilodeau M, Laplante M, Tang A, Faraj M, Estall JL. (2023). IL-6 Trans-Signaling Is Increased in Diabetes, Impacted by Glucolipotoxicity, and Associated With Liver Stiffness and Fibrosis in Fatty Liver Disease.;72(12):1820-1834. doi: 10.2337/db23-0171.

26. Galun E. (2024). GENE THERAPY: FROM TECHNOLOGY TO REALITY.Harefuah.;163(2):97-101.

27. Poch T, Bahn J, Casar C, Krause J, Evangelakos I, Gilladi H, Kunzmann LK, Laschtowitz A, Iuso N, Schäfer AM, Liebig LA, Steinmann S, Sebode M, Folseraas T, Engesæter LK, Karlsen TH, Franke A, Hubner N, Schlein C, Galun E, Huber S, Lohse AW, Gagliani N, Schwinge D, Schramm C. (2024). Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis. Cell Rep Med.;5(7):101620. doi: 10.1016/j.xcrm.2024.101620.

28. Tomer Friehmann, Yamama Abu Mohsen, Yehuda Schlesinger, Lucy Ghantous, Lika Gamaev, Chavah Landau Zenilman, Avi Harazi, Eithan Galun, Daniel S Goldenberg. (2025). The oncogenic microRNA miR-222 promotes human LINE-1 retrotransposition. RNA Biol. (1):1-15. doi: 10.1080/15476286.2025.2511318.